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KMID : 1144120200100020309
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Biomedical Engineering Letters
2020 Volume.10 No. 2 p.309 ~ p.319
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A promising wound dressing based on alginate hydrogels containing vitamin D3 cross-linked by calcium carbonate/D-glucono-δ-lactone
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Ehterami Arian
Salehi Majid
Farzamfar Saeed
Samadian Hadi
Vaez Ahmad
Sahrapeyma Hamed
Ghorbani Sadegh
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Abstract
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In the present study, we fabricated vitamin D3-loaded alginate hydrogel and assessed its wound healing capability in the animal model. The various concentrations of vitamin D3 were added to the pre-dissolved sodium alginate in deionized water and cross-linked by calcium carbonate in combination with D-glucono-δ-lactone. The microstructure, swelling behavior, weight loss, hemo- and cytocompatibility of the fabricated hydrogels were evaluated. In the last stage, the therapeutic efficacy of the prepared hydrogels was evaluated in the full-thickness dermal wound model. The scanning electron microscopy images showed that the prepared hydrogel was highly porous with the porosity of 89.2?±?12.5% and contained the interconnected pores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about 89% in 14 days. The results showed that the prepared hydrogels were hemo- and cytocompatible. The animal study results implied that alginate hydrogel/3000 IU vitamin D3 group exhibited the highest wound closure present which was statistically significant than the control group (p?
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KEYWORD
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Tissue engineering, Alginate hydrogel, Vitamin D3, Skin, Wound healing
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